Pascual M R, Lazo R, Fernandez L, Lage A
Neoplasma. 1982;29(4):453-61.
The techniques used for determination of hormone receptors have provided a biochemical basis to the concept of hormone-dependence in breast cancer. By medical experience clinical factors were established for determination of hormonal treatment in breast tumors. The criteria used need now to be re-evaluated in terms of hormone receptor contents. We analysed a group of 155 patients with histologically confirmed breast carcinoma in which estradiol receptor determination was performed. Of these tumors 54% had more than 10 fmol of estradiol per mg protein. Menopause, advanced age, late first childbirth, obesity, early menopause and nuliparity were associated, in that order, with the presence of estrogen receptors in breast tumors. Prognostic stratification analysis brought out polar groups of estrogen receptor contents. Young, premenopausal women with children had only 16% estrogen receptor-positive tumors. Postmenopausal women, either without children or with late first childbirth had as much as 81% of estrogen receptor containing tumors. Clinical variables related to the presence of estrogen receptor positive tumors in the breast cancer population were coincident to risk factors for breast cancer in the healthy population. Possible implications of this coincidences are discussed.
用于测定激素受体的技术为乳腺癌激素依赖性概念提供了生化基础。根据医学经验，确立了用于确定乳腺肿瘤激素治疗的临床因素。现在需要根据激素受体含量对所使用的标准进行重新评估。我们分析了一组155例经组织学确诊的乳腺癌患者，对其进行了雌二醇受体测定。在这些肿瘤中，54%每毫克蛋白质的雌二醇含量超过10飞摩尔。绝经、高龄、初产晚、肥胖、早绝经和未育依次与乳腺肿瘤中雌激素受体的存在相关。预后分层分析显示了雌激素受体含量的两极分化组。有孩子的年轻绝经前女性只有16%的肿瘤雌激素受体呈阳性。无子女或初产晚的绝经后女性，高达81%的肿瘤含有雌激素受体。乳腺癌人群中与雌激素受体阳性肿瘤存在相关的临床变量与健康人群中乳腺癌的危险因素一致。讨论了这种一致性的可能影响。
