El Nahas A M, Lechler R, Zoob S, Rees A J
Proc Eur Dial Transplant Assoc. 1983;20:623-8.
The role of the immune system in the progression of experimental nephrotoxic serum nephritis (NTN) in rats has been evaluated. Proteinuria and renal functional impairment during the sub-acute phase of the disease determined the long-term prognosis of the nephritis regardless of the humoral autologous antibody levels. In contrast to the acute, immune mediated glomerulonephritis, chronic glomerular scarring in NTN proceeds independently of the host immune response.
免疫系统在大鼠实验性肾毒性血清肾炎（NTN）进展中的作用已得到评估。疾病亚急性期的蛋白尿和肾功能损害决定了肾炎的长期预后，而与体液自身抗体水平无关。与急性免疫介导的肾小球肾炎不同，NTN中的慢性肾小球瘢痕形成独立于宿主免疫反应而进展。
