对神经降压素行为效应的选择性耐受

Elective tolerance to behavioral effects of neurotensin.

作者信息

Rinkel G J, Hoeke E C, van Wimersma Greidanus T B

出版信息

Physiol Behav. 1983 Oct;31(4):467-70. doi: 10.1016/0031-9384(83)90067-7.

Abstract

Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the open field do not result in a reduction of locomotor activity. These findings make development of tolerance to this behavioral effect of neurotensin likely. Such a development of tolerance to neurotensin is not observed for the effect on responsiveness to electric footshock.

摘要

神经降压素可降低在旷场环境中的运动活性以及对电击足底的反应性。在旷场中重复注射神经降压素并结合对运动活性的重复测试，以及在旷场中仅重复注射神经降压素而不进行此类测试，均不会导致运动活性降低。这些发现表明，对神经降压素的这种行为效应产生耐受性的可能性很大。对于神经降压素对电击足底反应性的影响，未观察到这种耐受性的产生。