皮下注射D，L-3-羟基丁酸和乙酰乙酸对大鼠食物摄入量的不同影响。

Different effects of subcutaneous D,L-3-hydroxybutyrate and acetoacetate injections on food intake in rats.

作者信息

Langhans W, Wiesenreiter F, Scharrer E

出版信息

Physiol Behav. 1983 Oct;31(4):483-6. doi: 10.1016/0031-9384(83)90070-7.

Abstract

Cumulative food intake following subcutaneous injection of D,L-3-hydroxybutyrate (DL3HB) or acetoacetate (AcAc) was investigated in rats, because ketone bodies might contribute to food intake regulation according to Kennedy's lipostatic hypothesis. In addition, the metabolic effects of DL3HB-injections were studied by measuring the levels of plasma D3HB, plasma non-esterified fatty acids (NEFA), plasma glycerol, blood glucose, and liver glycogen. Subcutaneously injected DL3HB (10 mmoles/kg body weight) significantly reduced feeding while equimolar AcAc did not. DL3HB-injection increased plasma D3HB and decreased plasma NEFA and plasma glycerol 1-2 hours after the injection but did not affect blood glucose or liver glycogen content. The data suggest that oxidation of D3HB to AcAc contributes to the inhibition of feeding following subcutaneous DL3HB-injection in rats.

摘要

根据肯尼迪的脂肪稳态假说，酮体可能参与食物摄入调节，因此研究了皮下注射D，L-3-羟基丁酸（DL3HB）或乙酰乙酸（AcAc）后大鼠的累积食物摄入量。此外，通过测量血浆D3HB、血浆非酯化脂肪酸（NEFA）、血浆甘油、血糖和肝糖原水平，研究了DL3HB注射的代谢效应。皮下注射DL3HB（10毫摩尔/千克体重）显著减少进食，而等摩尔的AcAc则没有。注射DL3HB后1至2小时，血浆D3HB升高，血浆NEFA和血浆甘油降低，但不影响血糖或肝糖原含量。数据表明，D3HB氧化为AcAc有助于皮下注射DL3HB后抑制大鼠进食。