Rajalakshmi M, Sehgal A, Pruthi J S, Anand Kumar T C
Steroids. 1983 May;41(5):587-95. doi: 10.1016/0039-128x(83)90024-7.
Freshly ejaculated spermatozoa from monkey and human were washed and incubated with tritium labelled androgens or estradiol to study the pattern of spermatozoa steroid metabolism. When equal concentrations of steroid substrates were used for incubation, monkey and human spermatozoa showed very similar pattern of steroid conversion. Spermatozoa from both species converted testosterone mainly to androstenedione, but reverse conversion of androstenedione to testosterone was negligible. Estradiol-17 beta was converted mainly to estrone. The close similarity between the spermatozoa of monkey and men in their steroid metabolic pattern indicates that the rhesus monkey could be an useful animal model to study the effect of drugs on the metabolic pattern of human spermatozoa.
对来自猴子和人类的新鲜射出精子进行洗涤，并与氚标记的雄激素或雌二醇一起孵育，以研究精子甾体代谢模式。当使用等量浓度的甾体底物进行孵育时，猴子和人类精子显示出非常相似的甾体转化模式。两个物种的精子都主要将睾酮转化为雄烯二酮，但雄烯二酮逆向转化为睾酮的情况可忽略不计。雌二醇-17β主要转化为雌酮。猴子和人类精子在甾体代谢模式上的密切相似性表明，恒河猴可能是研究药物对人类精子代谢模式影响的有用动物模型。
