Katz S, Williams L F
Am J Surg. 1978 Jun;135(6):791-4. doi: 10.1016/0002-9610(78)90166-6.
The present therapeutic approach to occlusive mesenteric disease is unable to alter its high mortality and morbidity. We attempted to stabilize the intestinal lysosomal population with steroid prior to revascularization and thus reduce the lysosomal effluent. Steroid delivery during the occlusive period was accomplished via retrograde venous flow in the portal system. During revascularization steroid was further infused via the superior mesenteric artery. Our experimental model compared systemic venous delivery with retrograde portal venous delivery of steroid. Analysis of tissue acid phosphatase levels suggested steroid delivery via retrograde portal venous flow is the most efficient method of lysosomal stabilization.
目前针对闭塞性肠系膜疾病的治疗方法无法改变其高死亡率和高发病率。我们试图在血管再通之前用类固醇稳定肠道溶酶体群体，从而减少溶酶体流出物。在闭塞期，通过门静脉系统的逆行静脉血流进行类固醇给药。在血管再通期间，通过肠系膜上动脉进一步注入类固醇。我们的实验模型比较了类固醇的全身静脉给药和门静脉逆行给药。组织酸性磷酸酶水平分析表明，通过门静脉逆行血流给药类固醇是溶酶体稳定的最有效方法。
