Korsbäck C, Höckerstedt K
Ann Chir Gynaecol. 1984;73(1):50-3.
In an earlier study we found that intravenous vasopressin infusion caused a profound decrease in intestinal and liver pO2. As vasopressin has been reported to be more effective when infused directly into the superior mesenteric artery, we have now studied the effects of this type of administration. Intestinal pO2 and pCO2 and liver pO2 were continuously recorded using a silicone elastomer tube as a tonometer. Vasopressin was infused in a dose of 2.75 mU/kg/min in twelve dogs for 45 minutes. Intestinal tissue pO2 decreased during 45 minute infusion period from 35 +/- 0.9 mmHg to 19 +/- 0.7 mmHg (p less than 0.001) and liver pO2 from 38 +/- 1.9 mmHg to 19 +/- 1.1 mmHg (p less than 0.005). Both values obtained in this study did not differ from those noted when the same dose of vasopressin was administered intravenously.
在一项早期研究中，我们发现静脉输注血管加压素会导致肠道和肝脏的氧分压显著降低。由于据报道，将血管加压素直接注入肠系膜上动脉时效果更佳，我们现在研究了这种给药方式的效果。使用硅胶弹性体管作为张力计持续记录肠道氧分压和二氧化碳分压以及肝脏氧分压。在12只犬中以2.75 mU/kg/分钟的剂量输注血管加压素45分钟。在45分钟的输注期间，肠道组织氧分压从35±0.9 mmHg降至19±0.7 mmHg（p<0.001），肝脏氧分压从38±1.9 mmHg降至19±1.1 mmHg（p<0.005）。本研究中获得的这两个值与静脉给予相同剂量血管加压素时记录的值无差异。
