[肾上腺切除及随后给予氢化可的松的大鼠大脑不同区域突触体中γ-氨基丁酸的摄取及谷氨酸脱羧酶活性]

[Uptake of gamma-aminobutyric acid and glutamate decarboxylase activity in synaptosomes of various regions of the brain of rats in adrenalectomy and in subsequent hydrocortisone administration].

作者信息

Mishunina T M, Kononenko V Ia

出版信息

Ukr Biokhim Zh (1978). 1983 Nov-Dec;55(6):647-51.

Abstract

The adrenalectomy in rats followed by a single hydrocortisone administration had no influence on the glutamate decarboxylase activity and maximum rate of [3H] GABA uptake by synaptosomes of hypothalamus, hippocampus and cerebral hemispheres. Km of [3H] GABA uptake by synaptosomes in the above mentioned brain regions under adrenalectomy decreases sharply; hydrocortisone administration increases Km of mediator uptake by hippocampus synaptosomes, and hydrocortisone in vitro increases Km of [3H] GABA uptake by hypothalamus synaptosomes.

摘要

大鼠肾上腺切除术后单次给予氢化可的松，对下丘脑、海马和大脑半球突触体的谷氨酸脱羧酶活性及[3H]GABA摄取最大速率无影响。肾上腺切除术后上述脑区突触体对[3H]GABA摄取的米氏常数急剧降低；给予氢化可的松可增加海马突触体对递质摄取的米氏常数，体外给予氢化可的松可增加下丘脑突触体对[3H]GABA摄取的米氏常数。

相似文献

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