Lilburn J K, Dundee J W, Moore J
Anaesthesia. 1978 Apr;33(4):315-21. doi: 10.1111/j.1365-2044.1978.tb12414.x.
A continuous infusion of ketamine, following an initial dose of 1 mg/kg, has been used as sole anaesthetic in over 200 adult patients. The pre-operative use of 4 mg lorazepam has made this acceptable with respect to emergence sequelae and dreams. The technique can be used with neuromuscular blocking drugs and controlled ventilation with air, but here pancuronium is best avoided because of excessive tachycardia and hypertension. Hypertonus was the main problem encountered in the non-relaxant cases. The amount of ketamine required for anaesthesia has been analysed in detail and recommendations on dosage are given. The cardiovascular effects have also been analysed in detail. There is a need for a similar investigation to be carried out in circumstances where inhalation agents are not available and where there is a shortage of anaesthetists.
在给予1毫克/千克的初始剂量后，持续输注氯胺酮已被用作200多名成年患者的唯一麻醉剂。术前使用4毫克劳拉西泮，在苏醒后遗症和梦境方面使这种方法可以接受。该技术可与神经肌肉阻滞药物一起使用，并采用空气控制通气，但由于会导致过度心动过速和高血压，最好避免使用泮库溴铵。在未使用松弛剂的病例中，肌张力亢进是主要问题。已详细分析了麻醉所需的氯胺酮用量，并给出了剂量建议。还详细分析了心血管效应。在无法获得吸入麻醉剂且麻醉师短缺的情况下，有必要进行类似的研究。
