Lilburn J K, Dundee J W, Nair S G, Fee J P, Johnston H M
Anaesthesia. 1978 Apr;33(4):307-11. doi: 10.1111/j.1365-2044.1978.tb12412.x.
The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied. These included three benzodiazepines, droperidol and 'neurolept' combinations and four commonly-used premedicants. When given intravenously 10 min before induction of anaesthesia flunitrazepam and lorazepam gave best results. In a subsequent study, these two benzodiazepines and diazepam were given intravenously 30-40 min before induction of anaesthesia. There was no doubt that 4 mg lorazepam gave the greatest protection and is worthy of further study in this respect.
研究了多种药物消除由2mg/kg氯胺酮诱导麻醉后出现的谵妄和不愉快梦境的能力。这些药物包括三种苯二氮䓬类药物、氟哌利多和“神经安定”合剂以及四种常用的术前用药。在麻醉诱导前10分钟静脉给药时，氟硝西泮和劳拉西泮效果最佳。在随后的研究中，这两种苯二氮䓬类药物和地西泮在麻醉诱导前30 - 40分钟静脉给药。毫无疑问，4mg劳拉西泮提供了最大程度的保护，在这方面值得进一步研究。
