Collier C B
Anaesthesia. 1978 May;33(5):454-61. doi: 10.1111/j.1365-2044.1978.tb12464.x.
Significant changes in the plasma electrolytes were found in a group of ninety-two female patients in the first 5 min following suxamethonium administration. The plasma potassium rose to a higher level in those patients who developed suxamethonium pains than in those who did not; the plasma calcium decreased in the former group, but increased in the latter. The plasma sodium decreased early in most patients, with the greatest reduction in those patients who did not develop symptoms. A decrease in the level of plasma calcium at 1 min correlated well with the incidence of 'the pains'. There were significant differences in the electrolyte changes, depending on whether thiopentone or Althesin was used for induction, but there was no difference in the incidence of suxamethonium pains. Suxamethonium pains are attributed to damaged muscle-spindles with enhanced calcium release playing an important part.
在一组92名女性患者中，发现琥珀胆碱给药后的前5分钟内血浆电解质有显著变化。出现琥珀胆碱疼痛的患者血浆钾升高幅度高于未出现疼痛的患者；前一组患者血浆钙降低，而后一组患者血浆钙升高。大多数患者血浆钠早期降低，未出现症状的患者降低幅度最大。1分钟时血浆钙水平降低与“疼痛”发生率密切相关。根据诱导时使用硫喷妥钠还是安泰酮，电解质变化存在显著差异，但琥珀胆碱疼痛的发生率没有差异。琥珀胆碱疼痛归因于肌梭受损，钙释放增加起重要作用。
