Kjellstrand P, Holmquist B, Mandahl N, Bjerkemo M
Acta Pharmacol Toxicol (Copenh). 1983 Nov;53(5):369-74. doi: 10.1111/j.1600-0773.1983.tb03437.x.
Seven different strains of mice (wild, C57BL, DBA, B6CBA, A/sn, NZB and NMRI) were continuously exposed to 150 ppm trichloroethylene (TCE) during 30 days. After exposure all strains showed large increases in liver weight, while changes in kidney and spleen weights were small. Plasma butyrylcholinesterase (BuChE) activity increased in males of all strains and in females of strains A/sn and NZB. The increase in the females was less than that of the corresponding males. We concluded that there are moderate, but in some cases, significant differences in TCE sensitivity between different mouse strains. The differences observed between sexes emphasizes the importance of specifying sex as well as strain when reporting on toxic effects.
七种不同品系的小鼠（野生型、C57BL、DBA、B6CBA、A/sn、NZB和NMRI）在30天内持续暴露于150 ppm的三氯乙烯（TCE）中。暴露后，所有品系的肝脏重量均大幅增加，而肾脏和脾脏重量变化较小。所有品系雄性以及A/sn和NZB品系雌性的血浆丁酰胆碱酯酶（BuChE）活性均升高。雌性的升高幅度小于相应雄性。我们得出结论，不同小鼠品系对TCE的敏感性存在中度差异，但在某些情况下差异显著。两性之间观察到的差异强调了在报告毒性效应时指定性别以及品系的重要性。
