Selstam G, Damber J E
Acta Physiol Scand. 1983 Nov;119(3):209-12. doi: 10.1111/j.1748-1716.1983.tb07329.x.
The function and size of the rat ventral prostate are stimulated by androgens and inhibited by estrogens. In order to test whether the blood flow in prostate is influenced in a similar fashion prostatic blood flow was measured after administration of human chorionic gonadotrophin (hCG) in rats with and without pretreatment of estradiol-17 beta (E2) and in rats castrated for five days with and without treatment with E2. Prostatic blood flow was measured with the microsphere technique, which allows blood flow measurement without any interference with the organ. E2 treatment resulted in a decreased prostatic blood flow in both intact and castrated rats, and blood flow was restored to normal in intact rats after hCG-injection. It was concluded that the E2 induced decrement of prostatic blood flow was at least in part mediated by a direct effect on the prostate.
大鼠腹侧前列腺的功能和大小受雄激素刺激，受雌激素抑制。为了检测前列腺血流是否以类似方式受到影响，在给予人绒毛膜促性腺激素（hCG）后，测量了未预先使用17β-雌二醇（E2）和预先使用E2的大鼠的前列腺血流，以及去势5天且未使用E2和使用E2处理的大鼠的前列腺血流。采用微球技术测量前列腺血流，该技术可在不干扰器官的情况下测量血流。E2处理导致完整大鼠和去势大鼠的前列腺血流均减少，hCG注射后完整大鼠的血流恢复正常。得出的结论是，E2诱导的前列腺血流减少至少部分是由对前列腺的直接作用介导的。
