哮喘患者血清、支气管灌洗和支气管肺泡灌洗中的总IgE和特异性IgE

Total and specific IgE in serum, bronchial lavage and bronchoalveolar lavage of asthmatic patients.

作者信息

Crimi E, Scordamaglia A, Crimi P, Zupo S, Barocci S

出版信息

Allergy. 1983 Nov;38(8):553-9. doi: 10.1111/j.1398-9995.1983.tb04139.x.

DOI:10.1111/j.1398-9995.1983.tb04139.x

Abstract

Total and specific IgE were assessed in serum, bronchial lavage (BL) and broncho-alveolar lavage (BAL) of allergic asthmatics and healthy controls. Serum total IgE were found to be correlated with total IgE in BAL but not in BL. Total IgE/K+ ratio in serum and BL was higher in asthmatics than in controls, while the total IgE/albumin ratio was significantly higher in asthmatics than in controls in serum but not in BL and BAL. The mean of specific IgE in serum and BL was significantly higher in the group of patients with positive specific bronchial provocation test (sBPT) than in the group with negative sBPT. Similar results were observed between specific IgE serum level and BL and prick tests (PT), which show that BL does not always reflect the total IgE level of serum; in asthmatics, albumin can not be used to determine the degree of dilution in the recovered fluids; as in the serum, there is agreement between specific IgE in BL and PT or sPBT results.

摘要

在过敏性哮喘患者和健康对照者的血清、支气管灌洗（BL）和支气管肺泡灌洗（BAL）中评估总IgE和特异性IgE。发现血清总IgE与BAL中的总IgE相关，但与BL中的总IgE不相关。哮喘患者血清和BL中的总IgE/K⁺比值高于对照组，而哮喘患者血清中的总IgE/白蛋白比值显著高于对照组，但在BL和BAL中并非如此。特异性支气管激发试验（sBPT）阳性患者组血清和BL中特异性IgE的平均值显著高于sBPT阴性组。在特异性IgE血清水平与BL和点刺试验（PT）之间观察到类似结果，这表明BL并不总是反映血清中的总IgE水平；在哮喘患者中，白蛋白不能用于确定回收液中的稀释程度；与血清一样，BL中的特异性IgE与PT或sPBT结果之间存在一致性。