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Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity.建立对阿糖腺苷耐药且缺乏腺苷脱氨酶活性的小鼠细胞系。
Antimicrob Agents Chemother. 1983 Dec;24(6):947-9. doi: 10.1128/AAC.24.6.947.
2
Carbocyclic arabinosyladenine, an adenosine deaminase resistant antiviral agent.碳环阿拉伯糖基腺嘌呤，一种抗腺苷脱氨酶的抗病毒剂。
J Med Chem. 1977 Apr;20(4):612-3. doi: 10.1021/jm00214a040.
3
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4
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Murine lymphocytes and lymphocyte cell lines secrete adenosine deaminase.小鼠淋巴细胞和淋巴细胞系分泌腺苷脱氨酶。
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Adenosine deaminase from deoxycoformycin-sensitive and -resistant rat hepatoma cells. Purification and characterization.来自对脱氧助间型霉素敏感和耐药大鼠肝癌细胞的腺苷脱氨酶。纯化与特性鉴定。
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10
Substrate specificity of adenosine deaminase: the role of the substituents at the 2'- and 3'-carbons of adenine nucleosides, of their configuration and of the conformation of the furanose ring.腺苷脱氨酶的底物特异性：腺嘌呤核苷2'-和3'-碳原子上取代基、其构型以及呋喃糖环构象的作用。
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Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives.奈普拉诺辛A、3-去氮奈普拉诺辛A及其5'-去甲衍生物的广谱抗病毒活性。
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本文引用的文献

1
Vidarabine: a preliminary review of its pharmacological properties and therapeutic use.阿糖腺苷：其药理特性与治疗用途的初步综述。
Drugs. 1980 Oct;20(4):267-82. doi: 10.2165/00003495-198020040-00002.
2
Isolation and preliminary characterization of 9-beta-d-arabinofuranosyladenine-resistant mutants of baby hamster cells.幼仓鼠细胞9-β-D-阿拉伯呋喃糖基腺嘌呤抗性突变体的分离与初步鉴定
Somatic Cell Genet. 1981 Mar;7(2):147-60. doi: 10.1007/BF01567654.
3
Alteration of ribonucleotide reductase in aphidicolin-resistant mutants of mouse FM3A cells with associated resistance to arabinosyladenine and arabinosylcytosine.
Somatic Cell Genet. 1981 Jan;7(1):27-42. doi: 10.1007/BF01544746.
4
Increased adenosine deaminase synthesis and messenger RNA activity in deoxycoformycin-resistant cells.脱氧助间型霉素抗性细胞中腺苷脱氨酶合成及信使核糖核酸活性增加。
J Biol Chem. 1983 Jan 10;258(1):41-4.
5
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.利用核苷激酶缺陷型突变体鉴定人淋巴细胞中9-β-D-阿拉伯呋喃糖基腺嘌呤的激活机制。
Cancer Res. 1981 Nov;41(11 Pt 1):4478-83.
6
Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts.5-氟脱氧尿苷抗性小鼠成纤维细胞中胸苷酸合成酶的过量产生。
Mol Cell Biol. 1982 Sep;2(9):1118-25. doi: 10.1128/mcb.2.9.1118-1125.1982.
7
Evaluation of 4-(2-hydroxyethyl)-1-piperazineëthanesulfonic acid (HEPES) as a tissue culture buffer.评估4-（2-羟乙基）-1-哌嗪乙磺酸（HEPES）作为组织培养缓冲液的性能。
Proc Soc Exp Biol Med. 1969 Jan;130(1):305-10. doi: 10.3181/00379727-130-33543.
8
Selective inhibition of nuclear DNA synthesis by 9- -D-arabinofuranosyl adenine in rat cells transformed by Rous sarcoma virus.9-β-D-阿拉伯呋喃糖基腺嘌呤对劳氏肉瘤病毒转化的大鼠细胞中核DNA合成的选择性抑制作用。
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1753-7. doi: 10.1073/pnas.69.7.1753.
9
Resistance to 9-beta-D-arabinofuranosyladenine in murine tumor cells.
Cancer Res. 1978 Aug;38(8):2314-6.
10
Isolation and characterization of tunicamycin resistant mutants from Chinese hamster ovary cells.从中国仓鼠卵巢细胞中分离并鉴定衣霉素抗性突变体。
J Cell Physiol. 1979 Oct;101(1):149-56. doi: 10.1002/jcp.1041010117.

建立对阿糖腺苷耐药且缺乏腺苷脱氨酶活性的小鼠细胞系。

Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity.

作者信息

Shipman C, Tong S L, Smith S H, Katlama N B, Drach J C

出版信息

Antimicrob Agents Chemother. 1983 Dec;24(6):947-9. doi: 10.1128/AAC.24.6.947.

DOI:10.1128/AAC.24.6.947
PMID:6660862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185413/
Abstract

A population of cells stably resistant to a concentration of arabinosyladenine 100-fold greater than that tolerated by wild-type cells was selected over a period of 15 months. The cells are not cross resistant to arabinosylcytosine and may have at least one kinase with altered substrate specificity.

摘要

在15个月的时间里，筛选出了一群对阿糖腺苷的耐受浓度比野生型细胞高100倍的稳定抗性细胞。这些细胞对阿糖胞苷没有交叉抗性，并且可能至少有一种底物特异性改变的激酶。