建立对阿糖腺苷耐药且缺乏腺苷脱氨酶活性的小鼠细胞系。
Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity.
作者信息
Shipman C, Tong S L, Smith S H, Katlama N B, Drach J C
出版信息
Antimicrob Agents Chemother. 1983 Dec;24(6):947-9. doi: 10.1128/AAC.24.6.947.
Abstract
A population of cells stably resistant to a concentration of arabinosyladenine 100-fold greater than that tolerated by wild-type cells was selected over a period of 15 months. The cells are not cross resistant to arabinosylcytosine and may have at least one kinase with altered substrate specificity.
摘要
在15个月的时间里，筛选出了一群对阿糖腺苷的耐受浓度比野生型细胞高100倍的稳定抗性细胞。这些细胞对阿糖胞苷没有交叉抗性，并且可能至少有一种底物特异性改变的激酶。
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