Mueller S M, Rusterholz D B
Artery. 1983;11(5):345-60.
We recently investigated the effect of chronic sympathetic denervation on the intact ear vasculature of normotensive rabbits and found an important long-term or trophic influence of sympathetic nerves on vascular structural properties. To determine the effect of coarctation hypertension on this relationship, we studied 12 wk old rabbits 8 wk after a unilateral superior cervical ganglionectomy and induction of coarctation hypertension. Successful denervation was demonstrated by a shift of the norepinephrine dose-response curve to the left in the denervated ears as well as a decreased threshold (p less than 0.05), an increased slope (p less than 0.02) and a decreased M50 (p less than 0.01) (the concentration of norepinephrine that produced 50% of the maximal vasoconstrictor response to norepinephrine). The flow-pressure curves of the denervated compared to the innervated ears at maximal dilation (used as a functional assessment of structural alterations) did not differ. The maximal pressor responses to vasopressin and barium chloride (used as an indication of smooth muscle mass) also did not differ. These results suggest that sympathetic innervation does not importantly influence blood vessel structure during coarctation hypertension in contrast to the changes we previously found in normotensive rabbits.
我们最近研究了慢性交感神经去神经支配对正常血压家兔完整耳部血管系统的影响，发现交感神经对血管结构特性具有重要的长期或营养性影响。为了确定缩窄性高血压对这种关系的影响，我们研究了12周龄的家兔，在单侧颈上神经节切除并诱发缩窄性高血压8周后进行观察。去神经支配成功的表现为，去神经支配耳部的去甲肾上腺素剂量-反应曲线向左移动，同时阈值降低（p<0.05）、斜率增加（p<0.02）以及M50降低（p<0.01）（产生去甲肾上腺素最大血管收缩反应50%的去甲肾上腺素浓度）。在最大扩张时（用作结构改变的功能评估），去神经支配耳部与有神经支配耳部的血流-压力曲线并无差异。对血管加压素和氯化钡的最大升压反应（用作平滑肌质量的指标）也没有差异。这些结果表明，与我们之前在正常血压家兔中发现的变化相反，在缩窄性高血压期间，交感神经支配对血管结构没有重要影响。
