Rusterholz D B, Mueller S M
Ann Neurol. 1982 Apr;11(4):365-71. doi: 10.1002/ana.410110408.
The hypothesis of this study is that the chronic presence of intact sympathetic innervation influences the structure, and thereby function, of the rabbit ear vascular bed, and that this influence may be age related. Therefore we examined the effect of chronic sympathetic denervation on vascular resistance of the rabbit ear nine to ten weeks after unilateral superior cervical ganglionectomy. Two age groups were studied: growing juvenile rabbits denervated at 4 weeks of age and adult rabbits denervated at 16 weeks. We assessed the flow-pressure (resistance) curves of the chronically denervated and contralateral innervated isolated rabbit ears during maximum dilation. The flow-pressure curve was significantly shifted downward in the denervated compared to the contralateral innervated ears of juvenile rabbits operated on at 4 weeks (p less than 0.001) but was not different in adult rabbits operated on at 16 weeks. These results support the concept that the sympathetic nerves chronically influence blood vessel properties in growing animals, apart from their acute effect on vasomotor tone.
本研究的假设是，完整的交感神经长期存在会影响兔耳血管床的结构，进而影响其功能，且这种影响可能与年龄有关。因此，我们在单侧颈上神经节切除术后九至十周，研究了慢性交感神经去神经支配对兔耳血管阻力的影响。研究了两个年龄组：4周龄时去神经支配的幼年生长兔和16周龄时去神经支配的成年兔。我们评估了在最大扩张期间慢性去神经支配和对侧有神经支配的离体兔耳的流量-压力（阻力）曲线。与4周龄接受手术的幼年兔的对侧有神经支配的耳朵相比，去神经支配的耳朵的流量-压力曲线明显向下移动（p小于0.001），但在16周龄接受手术的成年兔中没有差异。这些结果支持了这样一种观点，即除了对血管运动张力的急性影响外，交感神经长期影响生长中动物的血管特性。
