Roehrs T, Zorick F, Koshorek G L, Wittig R, Roth T
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):371S-376S. doi: 10.1111/j.1365-2125.1983.tb02312.x.
Effects of ingestion of brotizolam (0.25 and 0.50 mg) over 1-3 days on polysomnographic measures of sleep were assessed in patients complaining of insomnia. Brotizolam reduced latency to sleep, number of awakenings and wake during sleep, and increased total sleep time. It also increased stage 2 sleep and decreased slow wave and rapid eye movement sleep. Increasing the dose from 0.25 to 0.50 mg increased hypnotic efficacy, and there was a more consistent and reliable effect. Discontinuation of brotizolam had minimal effects on sleep compared with placebo over the 3 nights after acute administration. No side-effects or disruption of daytime function was found using questionnaires and objective tests of performance.
在主诉失眠的患者中评估了连续1 - 3天摄入溴替唑仑（0.25毫克和0.50毫克）对睡眠多导睡眠图测量指标的影响。溴替唑仑缩短了入睡潜伏期、觉醒次数和睡眠期间的觉醒时间，并增加了总睡眠时间。它还增加了2期睡眠时间，减少了慢波睡眠和快速眼动睡眠。将剂量从0.25毫克增加到0.50毫克可提高催眠效果，且效果更一致、更可靠。与急性给药后3晚的安慰剂相比，停用溴替唑仑对睡眠的影响最小。通过问卷调查和客观性能测试未发现副作用或白天功能受到干扰。
