溴替唑仑对慢性失眠症患者睡眠的影响。
Effects of brotizolam on the sleep of chronic insomniacs.
作者信息
Mamelak M, Csima A, Price V
出版信息
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):377S-382S. doi: 10.1111/j.1365-2125.1983.tb02313.x.
Effects of 0.5 mg brotizolam on the sleep of chronic insomniacs were assessed electroencephalographically and subjectively over 14 days. Brotizolam (0.5 mg) increased total sleep time, decreased drowsy (stage 1) sleep and increased stage 2 sleep. At this dose it also decreased slow wave and rapid eye movement sleep. On withdrawal there was evidence of insomnia in some subjects during the first night. The drug was well tolerated. Further studies are indicated with lower doses of the drug.
通过脑电图和主观评估，对慢性失眠症患者连续14天使用0.5毫克溴替唑仑后的睡眠效果进行了评估。溴替唑仑（0.5毫克）可增加总睡眠时间，减少困倦（第1阶段）睡眠，并增加第2阶段睡眠。在此剂量下，它还会减少慢波睡眠和快速眼动睡眠。停药后的第一个晚上，部分受试者出现失眠迹象。该药物耐受性良好。建议对更低剂量的该药物进行进一步研究。
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