Terletskaia Ia T, Kocherga V I, Kozulina E P, Syrovatskaia L P, Miroshnikov A I
Biokhimiia. 1983 Nov;48(11):1799-803.
The effect of presynaptic neurotoxin from bee and cobra venom--phospholipases A2 on Na+-dependent high affinity [14C]choline transport from the striate body of rat brain into synaptosomes has been studied. It was shown that both phospholipases A2 inhibit the re-uptake of [14C]choline and specifically stimulate the release of [14C]acetylcholine from the synaptosomes. This effect is especially well-pronounced for bee venom phospholipase A2. It was assumed that damages of biochemical processes on the presynaptic membrane result in a blockade of synaptic transmission in nerve-muscle preparations.
对蜜蜂和眼镜蛇毒液中的突触前神经毒素——磷脂酶A2对大鼠脑纹状体中Na+依赖性高亲和力[14C]胆碱转运至突触体的影响进行了研究。结果表明，两种磷脂酶A2均抑制[14C]胆碱的再摄取，并特异性地刺激[14C]乙酰胆碱从突触体中释放。这种效应在蜜蜂毒液磷脂酶A2中尤为明显。据推测，突触前膜上生化过程的损伤导致神经肌肉制剂中突触传递的阻断。
