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神经毒性磷脂酶A2对突触体摄取γ-氨基丁酸的抑制作用。

Inhibition by neurotoxic phospholipases A2 of synaptosomal uptake of gamma-aminobutyric acid.

作者信息

Ng R H, Howard B D

出版信息

J Neurochem. 1981 Jan;36(1):310-2. doi: 10.1111/j.1471-4159.1981.tb02412.x.

DOI:10.1111/j.1471-4159.1981.tb02412.x
PMID:7463056
Abstract

A comparison has been made of the abilities of several neurotoxic and nontoxic phospholipases A2 from snake venoms to inhibit the intake of gamma-aminobutyric acid into synaptosomes from rat cerebral cortex. The neurotoxic phospholipase A2 inhibited GABA uptake more than the nontoxic enzymes did. However, there was a poor correlation between the measured specific enzyme activity of a phospholipase A2 and its ability to inhibit the uptake of GABA.

摘要

对几种来自蛇毒的神经毒性和无毒磷脂酶A2抑制γ-氨基丁酸摄入大鼠大脑皮质突触体的能力进行了比较。神经毒性磷脂酶A2比无毒酶更能抑制γ-氨基丁酸的摄取。然而，磷脂酶A2的实测比酶活性与其抑制γ-氨基丁酸摄取的能力之间相关性较差。

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