关于膜形成的统计热力学

On the statistical thermodynamics of membrane formation.

作者信息

Leermakers F A, Scheutjens J M, Lyklema J

出版信息

Biophys Chem. 1983 Nov;18(4):353-60. doi: 10.1016/0301-4622(83)80048-9.

Abstract

Modifying a procedure developed by Scheutjens and Fleer (J. Phys. Chem. 83 (1979) 1619; J. Phys. Chem. 84 (1980) 178) to describe adsorption of polymers, a lattice theory is proposed to formulate the formation and properties of amphiphilic bilayer membranes. In this theory individual conformations are distinguished and lateral interactions are taken into account in a Flory-Huggins approximation. Probability distributions of head, tail and solvent segments are computed and it is shown that they are not narrow, i.e., membrane properties are subject to considerable fluctuations. The average concentration of the water in the hydrophobic core is nonzero. Various extensions, consequences and applications are proposed.

摘要

通过修改Scheutjens和Fleer开发的一种程序（《物理化学杂志》83卷（1979年）1619页；《物理化学杂志》84卷（1980年）178页）来描述聚合物的吸附，提出了一种晶格理论来阐述两亲性双层膜的形成和性质。在该理论中，区分了单个构象，并在弗洛里-哈金斯近似中考虑了横向相互作用。计算了头部、尾部和溶剂段的概率分布，结果表明它们并不狭窄，即膜的性质会受到相当大的波动影响。疏水核心中水分子的平均浓度不为零。还提出了各种扩展、结论和应用。