Meyer M C, Raghow G, Straughn A B
Biopharm Drug Dispos. 1983 Oct-Dec;4(4):401-4. doi: 10.1002/bdd.2510040412.
Fourteen healthy human subjects received a 200 mg oral dose of ethaverine hydrochloride as an elixir. Blood samples were obtained for 12 h after dosing. Plasma ethaverine concentrations were determined using a paired-ion, reversed-phase high performance liquid chromatographic method. Individual plasma concentration-time profiles were fitted to a two-compartment model with first-order absorption. The ethaverine was rapidly absorbed, based on a time of maximum plasma concentration of 0.75 h, a time-lag of 8.4 min, and an apparent first-order absorption half-life of 8.6 min. The mean terminal elimination half-life was 3.3 h.
14名健康受试者口服了200毫克盐酸乙苯福林酏剂。给药后12小时采集血样。采用离子对反相高效液相色谱法测定血浆中乙苯福林的浓度。将个体血浆浓度-时间曲线拟合为具有一级吸收的二室模型。根据血浆浓度达峰时间为0.75小时、时滞为8.4分钟以及表观一级吸收半衰期为8.6分钟，可知乙苯福林吸收迅速。平均终末消除半衰期为3.3小时。
