Arnold J D, Baldridge J, Riley B, Brody G
Int J Clin Pharmacol Biopharm. 1977 May;15(5):230-3.
The bioavailability of papaverine, administered as sustained release capsules, an elixir, and soft gelatin capsules, was studied with volunteers. Blood samples were assayed for papaverine, using a gas chromatographic method, following the administration of single 150 mg doses of papaverine HC1. The elixir and the soft gelatin capsule resulted in nearly identical papaverine blood levels, while peak levels, area under the blood level-time curve, and plasma levels 0.5, 1.0, 1.5, and 2.0 hours after dosing with the sustained release capsule were significantly (p less than 0.01) lower.
以志愿者为对象，研究了作为缓释胶囊、酏剂和软胶囊给药的罂粟碱的生物利用度。在单次给予150mg盐酸罂粟碱后，采用气相色谱法对血样中的罂粟碱进行检测。酏剂和软胶囊产生的罂粟碱血药浓度几乎相同，而服用缓释胶囊后0.5、1.0、1.5和2.0小时的血药峰浓度、血药浓度-时间曲线下面积和血浆浓度则显著（p<0.01）较低。
