Vakulina T P, Markov Kh M, Pinelis V G, Kozlov A V, Mukhammedov A
Biull Eksp Biol Med. 1983 Dec;96(12):22-5.
Structurally based resistance and vascular reactivity of the posterior body to noradrenaline were studied in normotensive rats and rats with DOCA-salt hypertension. The hypertension was induced in rats with intact sympathetic nervous system and in rats subjected to neonatal sympathectomy with guanethidine. During the prehypertensive stage, vascular sensitivity of the smooth muscles to noradrenaline was enhanced, with structural lesions being observed only in steady hypertension. Elevation of arterial pressure was accompanied by an increased vascular response to the stimulation of the sympathetic nerves. Sympathectomy prevented arterial pressure elevation and structural alterations in the vessels.
在正常血压大鼠和去氧皮质酮-盐性高血压大鼠中，研究了后体基于结构的对去甲肾上腺素的抗性和血管反应性。高血压在交感神经系统完整的大鼠和用胍乙啶进行新生期交感神经切除术的大鼠中诱发。在高血压前期，平滑肌对去甲肾上腺素的血管敏感性增强，仅在持续性高血压中观察到结构损伤。动脉血压升高伴随着对交感神经刺激的血管反应增加。交感神经切除术可防止动脉血压升高和血管结构改变。
