Diaz J, Moore E, Petracca F, Stamper C
Brain Res Bull. 1983 Dec;11(6):643-7. doi: 10.1016/0361-9230(83)90006-0.
Rearing preweanling rat pups away from their mothers by feeding through chronic intragastric cannulas has been shown to result in alterations in the growth of specific organs. In the present study, artificially reared (AR) rats and their normally reared (NR) siblings were sacrificed at various ages during this procedure to determine the time course of these alterations. Brain growth deficits were detected within 24 hours, peaked after 8 days of artificial rearing and showed some recovery by the end of the study. By day 18, the livers, kidneys and spleens of the AR pups were significantly larger than those of their NR siblings. The spleens showed an initial decrease in weight compared to the spleens of the NR pups. However, by day 18, the spleens of the AR group were significantly larger than those of the NR group.
通过长期胃内插管喂养使断奶前的幼鼠与其母亲分离，已被证明会导致特定器官生长的改变。在本研究中，在此过程中的不同年龄段处死人工饲养（AR）的大鼠及其正常饲养（NR）的同窝幼鼠，以确定这些改变的时间进程。在24小时内检测到脑生长缺陷，在人工饲养8天后达到峰值，并在研究结束时显示出一定程度的恢复。到第18天，AR幼鼠的肝脏、肾脏和脾脏明显大于其NR同窝幼鼠的相应器官。与NR幼鼠的脾脏相比，AR幼鼠的脾脏重量最初有所下降。然而，到第18天，AR组的脾脏明显大于NR组的脾脏。
