Kelton J G, Ulan R, Stiller C, Holmes E
Ann Intern Med. 1978 Jul;89(1):67-70. doi: 10.7326/0003-4819-89-1-67.
It is hypothesized that peritoneal fluid might be used as an alternative vehicle for monitoring the clinical chemistry of patients on peritoneal dialyses and save these patients the venesection and resultant blood loss. Peritoneal fluid was obtained before 47.2% of 106 dialysis treatments and compared with simultaneous serum samples. Very close correlation was noted for phosphorus, uric acid, blood urea nitrogen, creatinine, potassium, bicarbonate, and sodium (r greater than 0.82, p less than 10(-6)), and we conclude that peritoneal fluid may be useful for monitoring these chemistries. The peritoneal fluid concentrations of calcium and albumin were consistently 20% and 43% lower than the corresponding serum values. Because the peritoneal fluid is in equilibrium with the serum, it could also be used to measure protein binding of low molecular-weight substances in vivo that cross the peritoneal membrane. The results presented here fail to support the suggestion that urate is bound to serum proteins in vivo.
据推测，腹膜液或许可作为一种替代手段，用于监测接受腹膜透析患者的临床化学指标，从而避免这些患者进行静脉穿刺及由此导致的失血。在106次透析治疗中，47.2%的治疗前获取了腹膜液，并与同时采集的血清样本进行比较。发现磷、尿酸、血尿素氮、肌酐、钾、碳酸氢盐和钠的相关性非常密切（r大于0.82，p小于10⁻⁶），我们得出结论，腹膜液可能有助于监测这些化学指标。腹膜液中钙和白蛋白的浓度始终分别比相应血清值低20%和43%。由于腹膜液与血清处于平衡状态，它还可用于测量体内穿过腹膜的低分子量物质的蛋白质结合情况。此处呈现的结果并不支持尿酸在体内与血清蛋白结合的观点。
