膜脂流动性与膜结合蛋白活性之间的关系：利多卡因对大鼠心肌腺苷酸环化酶活性的影响。
Relationship between the fluidity of the membrane lipids and the activity of the membrane-bound proteins: the effects of lidocaine on the adenylate cyclase activity of rat myocardium.
作者信息
Illiano G, Chiosi E, Draetta G F, Laurenza A
出版信息
Gen Pharmacol. 1983;14(6):669-72. doi: 10.1016/0306-3623(83)90165-9.
The lidocaine effects on the basal adenylate cyclase activity of the studied membranes depend on the substrate concentration: the drug has an inhibiting effect on non-saturating ATP concentrations, but displays a stimulating effect on the saturating ones. In the presence of maximally stimulating NaF concentrations, lidocaine further stimulates the adenylate cyclase activity through all the ATP concentrations used. In the presence of ATP saturating concentrations, the adenylate cyclase activity stimulated by various Gpp(NH)p concentrations, is inhibited in the presence of lidocaine as well as the enzymic activity stimulated by several l-isoproterenol concentrations in the presence of a fixed Gpp(NH)p concentration.
利多卡因对所研究细胞膜的基础腺苷酸环化酶活性的影响取决于底物浓度
该药物对非饱和ATP浓度有抑制作用，但对饱和ATP浓度则表现出刺激作用。在存在最大刺激浓度的氟化钠时，利多卡因在所用的所有ATP浓度下均进一步刺激腺苷酸环化酶活性。在ATP饱和浓度存在的情况下，由各种Gpp(NH)p浓度刺激的腺苷酸环化酶活性，在利多卡因存在时会受到抑制，并且在固定的Gpp(NH)p浓度存在时，由几种L-异丙肾上腺素浓度刺激的酶活性也会受到抑制。
Zotero 插件