Van Brabandt H, Cauberghs M, Verbeken E, Moerman P, Lauweryns J M, Van de Woestijne K P
J Appl Physiol Respir Environ Exerc Physiol. 1983 Dec;55(6):1733-42. doi: 10.1152/jappl.1983.55.6.1733.
Partitioning of pulmonary resistance of 15 excised human and 5 canine lungs by means of a retrograde catheter demonstrated that the share of peripheral airways (with an ID of 2.4 mm or less) and of lung tissue in pulmonary resistance was markedly larger (44-96%) in humans than in dogs (41-59%). Similar percentages were found in patients with chronic obstructive pulmonary disease (COPD). The variations of resistance with volume during deflation and inflation of the lungs were due primarily to variations of peripheral resistance (Rp). The latter systematically increased at high and low lung volumes. Higher Rp values, with a more pronounced frequency dependence, were met in patients with COPD. A morphometrical study showed an inverse relationship between the value of Rp and the mean diameter of the terminal bronchioles, provided the airways density was taken into account.
通过逆行导管对15个离体人肺和5个犬肺的肺阻力进行划分，结果表明，在肺阻力中，人类外周气道（内径为2.4毫米或更小）和肺组织所占的比例（44%-96%）明显高于犬类（41%-59%）。慢性阻塞性肺疾病（COPD）患者也发现了类似的百分比。肺在呼气和吸气过程中阻力随容积的变化主要归因于外周阻力（Rp）的变化。外周阻力在高肺容积和低肺容积时系统性增加。COPD患者的Rp值更高，且频率依赖性更明显。一项形态计量学研究表明，若考虑气道密度，Rp值与终末细支气管的平均直径呈负相关。
