Fernandes C J, Stevens D A, Murray S I, Ackerman V P
J Antimicrob Chemother. 1983 Dec;12(6):577-85. doi: 10.1093/jac/12.6.577.
A number of newer antibiotics, broad-spectrum penicillins and cephalosporins, have been evaluated against Gram-negative rods. The organisms were selected for multi-resistance and transferable resistance factors. None of the broad-spectrum penicillins was much use against most of the organisms. Ceftriaxone, cefotaxime, latamoxef (moxalactam) and N-formimidoyl thienamycin were all highly effective against most multi-resistant Gram-negative bacilli; cefoperazone being inferior to them. Enterobacter and Serratia strains were relatively resistant to all the agents mentioned and against Acinetobacter only N-formimidoyl thienamycin showed much activity. Thus, use of these drugs may increase the proportion of infections due to organisms such as Serratia or Acinetobacter.
已对多种新型抗生素、广谱青霉素和头孢菌素针对革兰氏阴性杆菌进行了评估。所选菌株具有多重耐药性和可转移的耐药因子。大多数广谱青霉素对大多数此类菌株作用不大。头孢曲松、头孢噻肟、拉氧头孢（羟羧氧酰胺菌素）和N-甲脒硫霉素对大多数多重耐药革兰氏阴性杆菌均非常有效；头孢哌酮则次之。肠杆菌属和沙雷氏菌属菌株对上述所有药物相对耐药，而对于不动杆菌属，只有N-甲脒硫霉素显示出较强活性。因此，使用这些药物可能会增加由沙雷氏菌属或不动杆菌属等菌株引起的感染比例。
