Fong I W
J Antimicrob Chemother. 1983 Dec;12(6):607-12. doi: 10.1093/jac/12.6.607.
A retrospective review of 20 patients with staphylococcal central nervous system (CNS) infections treated with cloxacillin is presented. Eleven of these patients had Staphylococcus aureus meningitis secondary to neurosurgery or spontaneously induced. Six patients had ventricular shunt or drainage infection, two secondary to Staph. aureus and five grew Staph. epidermidis (with one mixed infection). Three patients presented with brain abscess, one with mixed anaerobic infection and all grew Staph. aureus. Cure with cloxacillin was achieved in 15 of the 20 patients. Failure of therapy was associated with doses of 6 g or less per day, and cure with doses of 12 g or more per day. Cloxacillin is effective in staphylococcal CNS infections when used in large parenteral doses.
本文对20例接受氯唑西林治疗的葡萄球菌中枢神经系统（CNS）感染患者进行了回顾性研究。这些患者中，11例患有继发于神经外科手术或自发感染的金黄色葡萄球菌脑膜炎。6例患有脑室分流或引流感染，其中2例继发于金黄色葡萄球菌，5例培养出表皮葡萄球菌（1例为混合感染）。3例患者出现脑脓肿，1例为混合厌氧菌感染，所有患者均培养出金黄色葡萄球菌。20例患者中有15例通过氯唑西林治愈。治疗失败与每日剂量6 g或更低有关，而每日剂量12 g或更高可实现治愈。大剂量胃肠外使用氯唑西林对葡萄球菌中枢神经系统感染有效。
