Roberts F J, Smith J A, Wagner K R
Can Med Assoc J. 1983 Jun 15;128(12):1418-20.
The records of all patients with Staphylococcus aureus meningitis admitted to Vancouver General Hospital between 1956 and 1981 were reviewed. All the patients had clinical and laboratory features of meningitis, and in all cases S. aureus was isolated from the cerebrospinal fluid. S. aureus was responsible for 21 (3%) of the 710 cases of acute bacterial meningitis. Therapy with cloxacillin or methicillin, or both, with or without other agents, was successful in 14 of the 21 patients. Three of the 14 patients without ventricular shunts died, 2 with fulminating septicemia and 1 with a postoperative brain abscess treated with cloxacillin. Following shunt removal and antibiotic therapy all seven patients with ventricular shunts survived the infection. Shunt removal may therefore be essential in appropriate cases.
回顾了1956年至1981年间入住温哥华总医院的所有金黄色葡萄球菌脑膜炎患者的记录。所有患者均有脑膜炎的临床和实验室特征，且所有病例的脑脊液中均分离出金黄色葡萄球菌。在710例急性细菌性脑膜炎病例中，金黄色葡萄球菌导致了21例（3%）。21例患者中，14例使用氯唑西林或甲氧西林，或两者并用，加或不加其他药物进行治疗取得了成功。14例无脑室分流的患者中有3例死亡，2例死于暴发性败血症，1例死于用氯唑西林治疗的术后脑脓肿。在移除分流管并进行抗生素治疗后，所有7例有脑室分流的患者均从感染中存活下来。因此，在适当的病例中，移除分流管可能至关重要。
