Lehane M J
Ann Trop Med Parasitol. 1978 Jun;72(3):285-8. doi: 10.1080/00034983.1978.11719317.
Cuticular abnormalities in larval Brugia pahangi at c. 12 hours post blood meal are the first signs of abnormal worm development in refractory Aedes aegypti. Normally developing B. pahangi undertakes large scale cuticular reorganization during the first larval stage, screting new cuticle to nearly six times the original volume. The inability of the first stage larva to carry out this cuticular reorganization in refractory A. aegypti is the basis of developmental abnormality. It is concluded that this failure on the part of the worm is caused by an alteration in the physiological environment of the flight muscle cells of refractory A. aegypti from that of susceptible A. aegypti.
在吸食血液约12小时后，感染了彭亨丝虫幼虫的埃及伊蚊体表出现异常，这是该虫在难治性埃及伊蚊体内发育异常的首个迹象。正常发育的彭亨丝虫在幼虫第一阶段会进行大规模的体表重组，分泌出的新表皮体积几乎是原来的六倍。在难治性埃及伊蚊体内，第一阶段幼虫无法进行这种体表重组，这是发育异常的基础。得出的结论是，这种丝虫的发育失败是由难治性埃及伊蚊飞行肌细胞的生理环境与易感埃及伊蚊的生理环境不同所致。
