Brown Z W, Amit Z, Sinyor D, Rockman G E, Ogren S O
Arch Int Pharmacodyn Ther. 1978 Mar;232(1):102-10.
Male Wistar rats were exposed to a free choice between water and a morphine-sucrose solution. Following stabilization of baseline levels of consumption of morphine, the animals were injected for 5 consecutive days with either FLA-57 (45 or 60 mg/kg i.p.), a non-toxic dopamine-beta-hydroxylase inhibitor or its vehicle. The FLA-57 treated animals significantly attenuated their preference for morphine during the injection and post-injection periods although there were no significant differences related to the dosages used. These treatments produced a concomitant reduction in central norepinephrine levels suggesting that norepinephrine may be involved in the mediation of the reinforcing properties of morphine consumed by laboratory rats. The possibility of common neural mechanisms regulating the pharmacological actions of both morphine and ethanol are discussed.
将雄性Wistar大鼠置于水和吗啡 - 蔗糖溶液之间进行自由选择。在吗啡消耗的基线水平稳定后，连续5天给动物注射无毒的多巴胺 - β - 羟化酶抑制剂FLA - 57（45或60mg / kg腹腔注射）或其溶媒。尽管所使用的剂量没有显著差异，但接受FLA - 57治疗的动物在注射期间和注射后对吗啡的偏好显著减弱。这些处理使中枢去甲肾上腺素水平同时降低，表明去甲肾上腺素可能参与介导实验大鼠摄入吗啡的强化特性。文中还讨论了调节吗啡和乙醇药理作用的共同神经机制的可能性。
