Brown Z W, Amit Z, Levitan D E, Ogren S O, Sutherland E A
Arch Int Pharmacodyn Ther. 1977 Nov;230(1):76-82.
Following stabilization of consumption of a 15% (v/v) ethanol solution in a free-choice with water, rats were presented with a forced-choice of ethanol for 10 consecutive alternate days. Prior to each forced-choice presentation experimental animals were injected with the non-toxic dopamine-beta-hydroxylase inhibitor FLA-57 (30 mg/kg i.p.) while control animals received only vehicle injections. At the termination of the injection phase when ethanol was again made available in a free-choice with water, ethanol consumption for the FLA-57 treated animals was markedly suppressed. These data are interpreted in terms of extinction resulting from the procedure whereby performance of the ethanol drinking response was perpetuated by force with the pharmacological reinforcing properties being blocked by FLA-57-induced depletions of norepinephrine. Applications of these procedures in the treatment of human alcoholics are discussed.
在大鼠自由选择饮用15%（v/v）乙醇溶液与水的摄入量稳定后，连续10个交替日对其进行乙醇强制选择实验。在每次强制选择实验前，给实验动物腹腔注射无毒的多巴胺-β-羟化酶抑制剂FLA-57（30mg/kg），而对照动物只注射溶剂。在注射阶段结束时，再次让动物自由选择饮用乙醇和水，结果发现FLA-57处理组动物的乙醇摄入量明显受到抑制。这些数据被解释为是由于该实验程序导致的消退现象，即乙醇饮用反应的表现因强制而持续存在，而药理学强化特性被FLA-57诱导的去甲肾上腺素耗竭所阻断。本文还讨论了这些程序在治疗人类酗酒者中的应用。
