Takeda R, Momose Y
Arch Int Pharmacodyn Ther. 1978 Mar;232(1):14-27.
The effect of acetaldehyde on the electrical and mechanical activities of the isolated segment of taenia coli from guinea-pigs has been studied using a sucrose-gap method. Application of acetaldehyde produces relaxation of the muscle, which is accompanied by reduction or cessation of spontaneous spike activity and hyperpolarization of the membrane. The hyperpolarization becomes smaller with lowering the temperature. These actions of acetaldehyde are not modified by adrenergic and cholinergic receptor blocking agents nor by tetrodotoxin and ouabain. Acetaldehyde also reduces the evoked activities produced by KCl, BaCl2, acetylcholine or electrical stimulation. The nonadrenergic inhibitory junction potential is reduced by acetaldehyde. When external Ca++ is replaced with Sr++ or Ba++, the action of acetaldehyde is suppressed. Addition of Mn++ eliminates the action of the aldehyde. Acetaldehyde relaxes the muscle when administered after fully developed membrane depolarization induced by K2SO4.
利用蔗糖间隙法研究了乙醛对豚鼠结肠带离体节段电活动和机械活动的影响。施加乙醛会使肌肉松弛，同时伴有自发尖峰活动的减少或停止以及膜的超极化。随着温度降低，超极化变小。乙醛的这些作用不受肾上腺素能和胆碱能受体阻断剂、河豚毒素和哇巴因的影响。乙醛还会降低由氯化钾、氯化钡、乙酰胆碱或电刺激产生的诱发活动。非肾上腺素能抑制性接头电位会被乙醛降低。当外部钙离子被锶离子或钡离子取代时，乙醛的作用受到抑制。添加锰离子可消除乙醛的作用。在硫酸钾诱导的完全膜去极化后给予乙醛，它会使肌肉松弛。
