大鼠和人脑组织中喹啉酸的鉴定。
Identification of quinolinic acid in rat and human brain tissue.
作者信息
Wolfensberger M, Amsler U, Cuénod M, Foster A C, Whetsell W O, Schwarcz R
出版信息
Neurosci Lett. 1983 Nov 11;41(3):247-52. doi: 10.1016/0304-3940(83)90458-5.
PMID:6664615
Abstract
An analytical technique for the determination of the excitotoxic compound quinolinic acid (2,3-pyridine dicarboxylic acid) in brain tissue has been developed. Following sample prepurification by ion exchange and high pressure liquid chromatography, quinolinic acid is converted to the dihexafluoroisopropyl ester and the derivative is analyzed by mass fragmentography. Using the present technique quinolinic acid has been identified in both rat and human brain tissue.
摘要
已开发出一种用于测定脑组织中兴奋性毒性化合物喹啉酸（2,3-吡啶二甲酸）的分析技术。通过离子交换和高压液相色谱对样品进行预纯化后，喹啉酸被转化为二六氟异丙酯，并通过质量碎片分析法对衍生物进行分析。使用本技术已在大鼠和人类脑组织中鉴定出喹啉酸。
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