Corbett D, Stellar J R
Physiol Behav. 1983 Dec;31(6):771-6. doi: 10.1016/0031-9384(83)90273-1.
Electrical stimulation of the medial prefrontal cortex (MFC) induced a moderate behavioral suppression in a series of neurological tests that included measures of (1) open field activity (2) righting and climbing reflexes (3) somatosensory reactivity and (4) approach-withdrawal responsiveness to positive and negative stimuli. The same animals were trained to lever press for medial prefrontal cortex stimulation and after several days of self-stimulation were again tested for neurological reactivity during MFC stimulation. No habituation or lessening of behavioral suppression was evident as a result of self-stimulation experience. Therefore behavioral suppression, by itself, cannot account for the slow acquisition of MFC self-stimulation. Other data suggest that the stimulation interferes with the learning of complex operant responses and/or that the reward value of the stimulation is increased as a result of repetition.
在一系列神经学测试中，对内侧前额叶皮质（MFC）进行电刺激会引起适度的行为抑制，这些测试包括：（1）旷场活动；（2）翻正和攀爬反射；（3）体感反应性；（4）对正负刺激的趋近-回避反应性。对同一批动物进行训练，使其按压杠杆以获得内侧前额叶皮质刺激，在经过几天的自我刺激后，再次测试它们在MFC刺激期间的神经反应性。自我刺激经验并未导致行为抑制出现习惯化或减轻。因此，行为抑制本身并不能解释MFC自我刺激的缓慢习得。其他数据表明，刺激会干扰复杂操作性反应的学习，和/或刺激的奖励价值会因重复而增加。
