Robertson A, Laferrière A, Milner P M
Physiol Behav. 1982 May;28(5):869-72. doi: 10.1016/0031-9384(82)90206-2.
Electrical stimulation of the medial prefrontal cortex (MC) in rats delivered daily for seven days causes a marked improvement in the rate of acquisition of a self-stimulation response. In the present experiment, we looked at whether we could get the same facilitatory effect on self-stimulation of the MC by delivering pre-training stimulation to other points in the brain anatomically related to the MC. Electrical stimulation of the lateral hypothalamus was without effect. However, electrical stimulation of the sulcal prefrontal cortex (SC) either contralateral or ipsilateral to the MC electrode did facilitate acquisition of self-stimulation of the MC. Thus the Sc and MC would appear to be part of the same substrate controlling the development of positive reinforcement in the MC.
连续七天每天对大鼠的内侧前额叶皮质（MC）进行电刺激，会使自我刺激反应的习得率显著提高。在本实验中，我们研究了通过对大脑中与MC在解剖学上相关的其他部位进行训练前刺激，是否能对MC的自我刺激产生相同的促进作用。对下丘脑外侧进行电刺激没有效果。然而，对与MC电极同侧或对侧的沟回前额叶皮质（SC）进行电刺激，确实促进了MC自我刺激的习得。因此，SC和MC似乎是控制MC中阳性强化发展的同一基质的一部分。
