Miller H R, Jackson F, Newlands G, Appleyard W T
Res Vet Sci. 1983 Nov;35(3):357-63.
The fate of exsheathed Haemonchus contortus larvae injected directly into the abomasal lumen was studied in groups of naive and hyperimmune sheep. Within 48 hours of challenge, more than 90 per cent of the larvae were lost from hyperimmune sheep. The larvae had a propensity to associate with the superficial mucus in both groups and, in naive sheep, approximately 50 per cent of the larvae entered glandular tissue within four hours of challenge. By contrast, although initially associated with the mucosal surface, larvae in immune sheep were excluded from the glandular tissues. It is postulated that the rapid loss of worms from the hyperimmune abomasum is a consequence of 'immune exclusion' and the possible mechanisms underlying this process are discussed.
在未感染过寄生虫和超免疫的绵羊群体中，研究了直接注射到皱胃腔中的去鞘捻转血矛线虫幼虫的命运。在攻击后的48小时内，超免疫绵羊体内90%以上的幼虫消失。两组中的幼虫都倾向于附着在表面黏液上，在未感染过寄生虫的绵羊中，约50%的幼虫在攻击后4小时内进入腺组织。相比之下，免疫绵羊中的幼虫虽然最初附着在黏膜表面，但被排除在腺组织之外。据推测，超免疫皱胃中蠕虫的快速消失是“免疫排斥”的结果，并讨论了这一过程的潜在机制。
