Incidence of experimental ochratoxicosis on hepatic disposition of [3H]tetracycline and chloramphenicol in rats.

[3H]Tetracycline or chloramphenicol were injected i.v. into anaesthetized controls and 12-day ochratoxin A-administered rats. The biliary excretion and hepatic levels of [3H]tetracycline were decreased whereas bile flow did not vary and plasma bioavailability of radioactivity increased in comparison with control rats. Ochratoxicosis induced also lower biliary excretion of glucuronide conjugated form of chloramphenicol without any change in its plasma or liver concentration.