Baloh R W, Yee R D, Honrubia V
Arch Neurol. 1978 Aug;35(8):490-3. doi: 10.1001/archneur.1978.00500320010003.
Smooth pursuit, optokinetic nystagmus (OKN) and the vestibulo-ocular reflex (VOR) were studied in four patients with internuclear ophthalmoplegia (two with bilateral and two with unilateral lesions). Horizontal smooth pursuit by an adducting eye on the side of a medial longitudinal fasciculus (MLF) lesion was normal in three of four patients; vertical pursuit was abnormal in all four. The horizontal VOR gain of slow components made by an adducting eye on the side of an MLF lesion was normal in all four patients. The vertical VOR gain was decreased in the two patients tested. It is concluded that either there are pathways independent of the MLF for horizontal pursuit and vestibular signals that are not available to vertical signals, or vertical pursuit and vestibular eye movements require a higher rate of oculomotor neuron firing than equal-velocity horizontal eye movements.
对4例核间性眼肌麻痹患者（2例双侧病变，2例单侧病变）进行了平稳跟踪、视动性眼震（OKN）和前庭眼反射（VOR）研究。在4例患者中，3例在内侧纵束（MLF）病变侧的内收眼进行水平平稳跟踪正常；4例患者的垂直跟踪均异常。在4例患者中，MLF病变侧内收眼产生的水平VOR慢相增益均正常。在2例接受测试的患者中，垂直VOR增益降低。结论是，要么存在独立于MLF的水平跟踪和前庭信号通路，而垂直信号无法利用这些通路，要么垂直跟踪和前庭眼动比等速水平眼动需要更高的动眼神经神经元放电率。
