蛋白质合成起始抑制剂2-（4-甲基-2,6-二硝基苯胺基）-N-甲基丙酰胺对萝卜幼苗核糖核酸合成的影响
Effect of the protein-synthesis-initiation inhibitor 2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide on ribonucleic acid synthesis in radish seedlings.
作者信息
Aspart L, Cooke R, Delseny M, Guitton Y
出版信息
Biochem J. 1978 Jun 1;171(3):607-11. doi: 10.1042/bj1710607.
Abstract
2-(4-Methyl-2,6-dinitroanilino)-N-methylpropionamide, an inhibitor of initiation of protein synthesis in plants, selectively alters rRNA synthesis. Ribosomal genes are transcribed in the absence of protein synthesis, but processing of the transcripts is impaired. This results in an accumulation of the 2.3 X 10(6)-dalton pre-rRNA. Synthesis of polyadenylated RNA is not affected by the drug.
摘要
2-（4-甲基-2,6-二硝基苯胺基）-N-甲基丙酰胺，一种植物蛋白质合成起始抑制剂，可选择性地改变核糖体RNA（rRNA）的合成。核糖体基因在没有蛋白质合成的情况下转录，但转录本的加工受到损害。这导致2.3×10⁶道尔顿的前体rRNA积累。聚腺苷酸化RNA的合成不受该药物影响。
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