Increased susceptibility to pentylenetetrazol-induced seizures in adult rats following electrical kindling during brain development.

The persistence of seizure susceptibility into adulthood following kindling in the immature rat was assessed. Rats kindled electrically at age 30 days were significantly more susceptible to pentylenetetrazol (PTZ)-induced seizures as adults than a control group. These findings demonstrate that kindling in the immature brain results in a permanent alteration in seizure susceptibility.