Holmes G L, Weber D A
Brain Res. 1983 Dec;313(2):312-4. doi: 10.1016/0165-3806(83)90230-4.
The persistence of seizure susceptibility into adulthood following kindling in the immature rat was assessed. Rats kindled electrically at age 30 days were significantly more susceptible to pentylenetetrazol (PTZ)-induced seizures as adults than a control group. These findings demonstrate that kindling in the immature brain results in a permanent alteration in seizure susceptibility.
评估了幼鼠点燃后癫痫易感性持续至成年期的情况。30日龄时经电点燃的大鼠成年后对戊四氮（PTZ）诱导的癫痫发作的易感性明显高于对照组。这些发现表明，幼年期脑内点燃会导致癫痫易感性发生永久性改变。
