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色氨酸和谷氨酸的热解产物在哺乳动物斑点试验中呈阳性。

Pyrolytic products from tryptophan and glutamic acid are positive in the mammalian spot test.

作者信息

Jensen N J

出版信息

Cancer Lett. 1983 Sep;20(2):241-4. doi: 10.1016/0304-3835(83)90055-1.

DOI:10.1016/0304-3835(83)90055-1
PMID:6667463
Abstract

Pyrolysates of tryptophan (Trp-P-2) and glutamic acid (Glu-P-1) are known mutagens in in vitro short term mutagenicity tests, and have also shown carcinogenic effects in long term animal studies. The present study demonstrates that they also produce mutations in somatic cells. This result demonstrates the ability of the test to detect carcinogenic and mutagenic compounds.

摘要

色氨酸(Trp-P-2)和谷氨酸(Glu-P-1)的热解产物在体外短期致突变性试验中是已知的诱变剂,并且在长期动物研究中也显示出致癌作用。本研究表明它们也会在体细胞中产生突变。这一结果证明了该试验检测致癌和诱变化合物的能力。

相似文献

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Pyrolytic products from tryptophan and glutamic acid are positive in the mammalian spot test.色氨酸和谷氨酸的热解产物在哺乳动物斑点试验中呈阳性。
Cancer Lett. 1983 Sep;20(2):241-4. doi: 10.1016/0304-3835(83)90055-1.
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Comparative induction of somatic eye-color mutations and sex-linked recessive lethals in Drosophila melanogaster by tryptophan pyrolysates.色氨酸热解产物对黑腹果蝇体细胞眼色突变和性连锁隐性致死的比较诱导作用。
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Presence of 3-amino-beta-carbolines (3-amino-9H-pyrido[3,4-b]indoles), effectors in the induction of sister-chromatid exchanges, in protein pyrolysates.
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Comparative genotoxic effects of the cooked-food-related mutagens Trp-P-2 and IQ in bacteria and cultured mammalian cells.熟食品相关诱变剂Trp-P-2和IQ在细菌及培养哺乳动物细胞中的比较遗传毒性效应。
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Mutagenic potency of heterocyclic amines in the Drosophila wing spot test and its correlation to carcinogenic potency.杂环胺在果蝇翅斑试验中的致突变效力及其与致癌效力的相关性。
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In vivo cytogenetic effects of the cooked-food-related mutagens Trp-P-2 and IQ in mouse bone marrow.熟食相关诱变剂Trp-P-2和IQ对小鼠骨髓的体内细胞遗传学效应。
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Effect of glutathione and uridine-5'-diphosphoglucuronic acid on the mutagenicity of tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by rat-liver and -intestine S9 fraction.
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Mutagenicities of gamma-carboline derivatives related to potent mutagens found in tryptophan pyrolysates.与色氨酸热解产物中发现的强效诱变剂相关的γ-咔啉衍生物的诱变性。
Carcinogenesis. 1980 May;1(5):451-4. doi: 10.1093/carcin/1.5.451.

引用本文的文献

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A current genotoxicity database for heterocyclic thermic food mutagens. I. Genetically relevant endpoints.杂环热食诱变剂的当前遗传毒性数据库。I. 与遗传相关的终点。
Environ Health Perspect. 1986 Aug;67:93-103. doi: 10.1289/ehp.866793.