Jensen N J
Cancer Lett. 1983 Sep;20(2):241-4. doi: 10.1016/0304-3835(83)90055-1.
Pyrolysates of tryptophan (Trp-P-2) and glutamic acid (Glu-P-1) are known mutagens in in vitro short term mutagenicity tests, and have also shown carcinogenic effects in long term animal studies. The present study demonstrates that they also produce mutations in somatic cells. This result demonstrates the ability of the test to detect carcinogenic and mutagenic compounds.
色氨酸(Trp-P-2)和谷氨酸(Glu-P-1)的热解产物在体外短期致突变性试验中是已知的诱变剂,并且在长期动物研究中也显示出致癌作用。本研究表明它们也会在体细胞中产生突变。这一结果证明了该试验检测致癌和诱变化合物的能力。