熟食相关诱变剂Trp-P-2和IQ对小鼠骨髓的体内细胞遗传学效应。
In vivo cytogenetic effects of the cooked-food-related mutagens Trp-P-2 and IQ in mouse bone marrow.
作者信息
Minkler J L, Carrano A V
出版信息
Mutat Res. 1984 Jun-Jul;140(2-3):49-53. doi: 10.1016/0165-7992(84)90041-1.
PMID:6749175
Abstract
Sister-chromatid exchange and chromosomal aberrations were measured in vivo in mouse bone marrow following intraperitoneal injection of the cooked food mutagens, Trp-P-2 and IQ. Trp-P-2 produced a significant positive dose response for both endpoints while IQ produced only a weak but significant sister-chromatid exchange response. The relative potency of these two chemicals is similar to that seen in mammalian cells in vitro but opposite to their potency in Salmonella.
摘要
在给小鼠腹腔注射烹饪食物诱变剂Trp-P-2和IQ后，对其体内骨髓中的姐妹染色单体交换和染色体畸变进行了测量。Trp-P-2在这两个终点上均产生了显著的阳性剂量反应，而IQ仅产生了微弱但显著的姐妹染色单体交换反应。这两种化学物质的相对效力与在体外哺乳动物细胞中观察到的相似，但与它们在沙门氏菌中的效力相反。
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