慢性高胰岛素血症对幼鼠脂肪生成和碳水化合物代谢相关肝酶的影响。
Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat.
作者信息
McCormick K L, Widness J A, Susa J B, Schwartz R
出版信息
Biochem J. 1978 May 15;172(2):327-31. doi: 10.1042/bj1720327.
Chronic (6 days) hyperinsulinaemia in young rats produced lower blood glucose concentrations and augmented body- and liver-weight gain. The insulin-treated rats had increased hepatic activities of citrate-cleavage enzyme, 'malic' enzyme and high-substrate (6.6 mM-phosphoenolpyruvate) pyruvate kinase, and decreased glucose 6-phosphatase. There were no changes in activities of phosphoenolpyruvate carboxykinase, phosphofructokinase, low-substrate (1.3 mM-phosphoenolpyruvate) pyruvate kinase, glucokinase and hexokinase.
幼鼠慢性（6天）高胰岛素血症导致血糖浓度降低，体重及肝脏重量增加。胰岛素处理的大鼠肝脏中柠檬酸裂解酶、“苹果酸”酶及高底物（6.6 mM磷酸烯醇丙酮酸）丙酮酸激酶的活性增加，而葡萄糖6磷酸酶活性降低。磷酸烯醇丙酮酸羧激酶、磷酸果糖激酶、低底物（1.3 mM磷酸烯醇丙酮酸）丙酮酸激酶、葡萄糖激酶和己糖激酶的活性没有变化。
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