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Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat.慢性高胰岛素血症对幼鼠脂肪生成和碳水化合物代谢相关肝酶的影响。
Biochem J. 1978 May 15;172(2):327-31. doi: 10.1042/bj1720327.
2
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本文引用的文献

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The influence of hormonal factors and of diet upon hepatic glucose-6-phosphatase activity.激素因素和饮食对肝脏葡萄糖-6-磷酸酶活性的影响。
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HORMONAL INDUCTION AND SUPPRESSION OF LIVER ENZYME BIOSYNTHESIS.肝脏酶生物合成的激素诱导与抑制
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PROPERTIES OF PHOSPHOFRUCTOKINASE FROM RAT LIVER AND THEIR RELATION TO THE CONTROL OF GLYCOLYSIS AND GLUCONEOGENESIS.大鼠肝脏磷酸果糖激酶的特性及其与糖酵解和糖异生调控的关系
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METABOLIC CONTROL OF ENZYMES INVOLVED IN LIPOGENESIS AND GLUCONEOGENESIS.脂肪生成和糖异生相关酶的代谢调控
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INSULIN-DEPENDENT SYNTHESIS OF LIVER GLUCOKINASE IN THE RAT.大鼠肝脏葡萄糖激酶的胰岛素依赖性合成
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EFFECTS OF DIET AND INSULIN ON GLUCOSE-ADENOSINE TRIPHOSPHATE PHOSPHOTRANSFERASES OF RAT LIVER.饮食与胰岛素对大鼠肝脏葡萄糖 - 三磷酸腺苷磷酸转移酶的影响。
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METABOLIC AND HORMONAL CONTROL OF PHOSPHOENOLPYRUVATE CARBOXYKINASE AND MALIC ENZYME IN RAT LIVER.大鼠肝脏中磷酸烯醇丙酮酸羧激酶和苹果酸酶的代谢与激素调控
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Incorporation of radioactive citrate into fatty acids.放射性柠檬酸盐掺入脂肪酸中。
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10
On the mechanism of gluconeogenesis and its regulation. II. The mechanism of gluconeogenesis from pyruvate and fumarate.论糖异生作用的机制及其调节。II. 由丙酮酸和富马酸生成糖异生的机制。
Biochem Z. 1965 Nov 15;343(2):176-91.

慢性高胰岛素血症对幼鼠脂肪生成和碳水化合物代谢相关肝酶的影响。

Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat.

作者信息

McCormick K L, Widness J A, Susa J B, Schwartz R

出版信息

Biochem J. 1978 May 15;172(2):327-31. doi: 10.1042/bj1720327.

DOI:10.1042/bj1720327
PMID:666750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1185699/
Abstract

Chronic (6 days) hyperinsulinaemia in young rats produced lower blood glucose concentrations and augmented body- and liver-weight gain. The insulin-treated rats had increased hepatic activities of citrate-cleavage enzyme, 'malic' enzyme and high-substrate (6.6 mM-phosphoenolpyruvate) pyruvate kinase, and decreased glucose 6-phosphatase. There were no changes in activities of phosphoenolpyruvate carboxykinase, phosphofructokinase, low-substrate (1.3 mM-phosphoenolpyruvate) pyruvate kinase, glucokinase and hexokinase.

摘要

幼鼠慢性（6天）高胰岛素血症导致血糖浓度降低，体重及肝脏重量增加。胰岛素处理的大鼠肝脏中柠檬酸裂解酶、“苹果酸”酶及高底物（6.6 mM磷酸烯醇丙酮酸）丙酮酸激酶的活性增加，而葡萄糖6磷酸酶活性降低。磷酸烯醇丙酮酸羧激酶、磷酸果糖激酶、低底物（1.3 mM磷酸烯醇丙酮酸）丙酮酸激酶、葡萄糖激酶和己糖激酶的活性没有变化。