Lemire R J
Clin Neurosurg. 1983;30:165-77. doi: 10.1093/neurosurgery/30.cn_suppl_1.165.
There are several approaches that can be applied to the analysis of malformations of the CNS. One practical way in making clinical correlations is to divide neural tube defects into those that arise during the period of neurulation and those that arise thereafter. This concept applies to cranial and spinal lesions and makes it possible to interpret clinical findings with embryological events. Malformations of the CNS that arise during the period of neurulation are not covered by skin and can be diagnosed prenatally by amniocentesis. Postneurulation CNS malformations are skin-covered and have differing patterns of associated malformation and etiologies. There is an overlap of the latter group with congenital tumors, and for the most part these malformations are not apt to be diagnosed prenatally.
有几种方法可应用于中枢神经系统畸形的分析。进行临床关联的一种实用方法是将神经管缺陷分为在神经胚形成期出现的和之后出现的。这一概念适用于颅骨和脊柱病变，使得根据胚胎学事件来解释临床发现成为可能。在神经胚形成期出现的中枢神经系统畸形没有皮肤覆盖，可通过羊膜穿刺术进行产前诊断。神经胚形成期后的中枢神经系统畸形有皮肤覆盖，且伴有不同模式的相关畸形和病因。后一组与先天性肿瘤有重叠，并且在很大程度上这些畸形不易于产前诊断。
