Oliveria Seth F, Thompson Eric M, Selden Nathan R
Medical Scientist Training Program, University of Colorado, Denver, Colorado, USA.
J Neurosurg Pediatr. 2010 Jun;5(6):626-9. doi: 10.3171/2010.2.PEDS09502.
Sacrococcygeal teratomas may arise in association with regional developmental errors affecting the caudal embryonic segments and may originate within lumbosacral lipomas. It is therefore possible that sacrococcygeal teratomas and lumbosacral lipomas represent related disorders of embryogenesis. Accordingly, the authors report the cases of 2 siblings. The first child (female) was born with a mature Altman Type III sacrococcygeal teratoma that was resected when she was a neonate. Subsequently, a younger brother was found soon after birth to have an L-4-level lipomyelomeningocele and underwent partial resection and spinal cord untethering at 4 months of age. Although familial forms of each of these conditions have been reported, this is, to the authors' knowledge, the first reported occurrence of lipomyelomeningocele and sacrococcygeal teratoma in siblings. They propose that an inherited regional tendency to developmental error affecting the caudal embryonic segments was shared by these siblings and resulted in spinal teratoma formation in one of them.
骶尾部畸胎瘤可能与影响尾侧胚胎节段的局部发育异常有关，并且可能起源于腰骶部脂肪瘤内。因此，骶尾部畸胎瘤和腰骶部脂肪瘤可能代表胚胎发生的相关疾病。相应地，作者报告了2例兄弟姐妹的病例。第一个孩子（女性）出生时患有成熟的奥特曼III型骶尾部畸胎瘤，在新生儿期接受了切除手术。随后，一个弟弟在出生后不久被发现患有L4水平的脂肪脊髓脊膜膨出，并在4个月大时接受了部分切除和脊髓松解手术。虽然每种疾病的家族性形式都有报道，但据作者所知，这是首次报道兄弟姐妹中出现脂肪脊髓脊膜膨出和骶尾部畸胎瘤。他们提出，这些兄弟姐妹共同具有影响尾侧胚胎节段的遗传性局部发育异常倾向，并导致其中一人形成脊髓畸胎瘤。
