Walsh P C
Prog Clin Biol Res. 1976;6:1-8.
The evidence for a hormonal etiology of BPH in man and the dog has been reviewed. Experimentally, although the administration of testosterone or dihydrotestosterone or dihydrotestosterone plus estradiol failed to produce BPH in the dog, treatment with androstanediol or androstanediol plus estradiol produces many of the features characteristic of canine prostatic hyperplasia. This development may provide an experimental model for exploration of the pathogenesis of prostatic hyperplasia.
有关人类和犬类良性前列腺增生（BPH）激素病因的证据已被综述。在实验中，尽管给予睾酮、双氢睾酮或双氢睾酮加雌二醇未能在犬类中诱发BPH，但用雄烷二醇或雄烷二醇加雌二醇进行治疗会产生许多犬前列腺增生的特征性表现。这一进展可能为探索前列腺增生的发病机制提供一个实验模型。
